Year: 2026
Type: preprint
Abstract: We show that the p53-Mdm2 gene interaction can be understood as a form of antithetic feedback, but with mixed feedback loops. In particular, we show that this viewpoint sheds light on the emergence and robustness properties of p53’s oscillatory behaviour, as observed experimentally.
Institutions: Digital Futures, KTH Royal Institute of Technology
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7220721125