Year: 2026
Type: article
Study design: Observational Study
Abstract: Aim: To determine the sensitivity and specificity of the Patient Health Questionnaire-9 (PHQ-9) for capturing general mental distress, defined as experiencing 5 or more severe mental health symptoms.Background The PHQ-9, originally designed as an assessment for depression, is now widely used as a first line screener in primary care and is often the sole mental health screener used. However, it is currently unknown how well the PHQ-9 performs as a general screener for mental distress. Methods: PHQ-9 responses were collected alongside responses to the transdiagnostic Mental Health Quotient (MHQ) assessment that captures 47 symptoms spanning 10 disorders as well as additional elements from RDoC in a sample of 5,750 respondents collected in 2022. PHQ-9 sum scores were compared with those with 5 or more symptoms from the MHQ.Findings: At a sum score cut-off corresponding to moderately severe depression, PHQ-9 had low sensitivity, capturing only 46% of those with general mental distress. At a cut-off corresponding to mild depression, sensitivity improved to 93%, while specificity dropped to 57%. Concurrently, the PHQ-9 missed several symptoms that were highly prevalent in the sample population and individuals with Severe PHQ-9 sum scores showed substantial heterogeneity in their overall symptom profiles.Altogether, the PHQ-9, due to its origin as a depression screener, performs poorly as a screener for general mental distress. In the context of primary care triage, this highlights the need for an alternative disorder agnostic first line screener that enables the identification of severe mental distress regardless of the specific profile of symptoms.
Source: Frontiers in Psychiatry
Institutions: Sapien Labs, University of California San Diego
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W7220734272