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Quantitative Relationship Between Lumipulse G Measures of pTau217 in Plasma and the Temporal Cortex

Year: 2026

Type: article

Study design: Observational Study

Abstract: BACKGROUND AND OBJECTIVES: ratio with cortical pTau217 levels measured using Lumipulse G immunoassays. METHODS: ratio were also measured. Generalized additive models and partial Spearman correlations were used to evaluate the relationship between blood and cortical pTau217. CIs were estimated using bootstrapping (5,000 iterations). RESULTS: > 0.19) remained significant after correction for the other pathology. DISCUSSION: levels in the temporal cortex.

Source: Neurology

DOI: 10.1212/wnl.0000000000218598

Authors: Steffi De Meyer, Sandra O. Tomé, Bas Lahaije, Jeroen Vanbrabant, Charlotte Lambrechts, Julie Goossens, Eugeen Vanmechelen, Kristel Sleegers, Christine A.F. Von Arnim, Thomas Tousseyn, Koen Poesen, Dietmar Rudolf Thal, Rik Vandenberghe

Institutions: KU Leuven, Fujirebio (Belgium), University of Antwerp, VIB-UAntwerp Center for Molecular Neurology, Universität Ulm, Universitair Ziekenhuis Leuven

Language: English

Topic: Dementia and Cognitive Impairment Research

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Cooley's Anemia Foundation, BrightFocus Foundation, Fonds Wetenschappelijk Onderzoek, KU Leuven

OpenAlex ID: W7220745389

FWCI:

Cites: 49

Cited by:

Related to: 10