Year: 2023
Type: article
Abstract: models.Mechanistically, Lpcat3 deficiency directly facilitates insulin receptor endocytosis, signal transduction and hepatic glucose production suppression, and indirectly enhances fibroblast growth factor 21 (FGF21) secretion, energy expenditure, and glucose uptake in adipose tissue.These findings identify hepatic LPCAT3 and membrane phospholipid composition as a novel regulator of insulin sensitivity and energy metabolism.The dissociation between NASH and insulin resistance in Lpcat3 liver knockout mice recapitulated the phenotype of a subpopulation of NASH patients and shed light on the pathogenesis of metabolic disorders.
Author: Tian, Ye
Language: English
Subfield: Hepatology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7220762147