Work

Disproportionality Signal Detection of Adverse Events Reported With Inclisiran in the FAERS Database

Year: 2026

Type: article

Abstract: Presented at STARS 2026. This project presents a comparative disproportionality analysis of adverse events associated with Inclisiran and Bempedoic Acid (BA) using data from the U.S. Food and Drug Administration Adverse Event Reporting System (FAERS) from 2022–2024. Reporting Odds Ratios (RORs) were calculated to identify safety signal patterns for each drug. Inclisiran demonstrated stronger reporting signals for metabolic abnormalities—including increased triglycerides, elevated hepatic enzymes, increased LDL‑C, increased blood glucose, and death—while BA showed higher reporting of musculoskeletal and gastrointestinal symptoms such as myalgia, nausea, and arthralgia. These findings provide real‑world pharmacovigilance insights to support clinical decision‑making for non‑statin lipid‑lowering therapies. The project includes a poster summarizing background, methods, results, and implications for public health and clinical practice.

Source: Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)

Author: Kumar, Karan

Institution: University of Illinois at Springfield

Language: English

Topic: Pharmacovigilance and Adverse Drug Reactions

Subfield: Toxicology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7220781429

FWCI:

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Related to: 10