Work

Design, synthesis, and in vitro antiproliferative evaluation of dasatinib/HO-1 inhibitor codrugs towards glioblastoma therapy

Year: 2026

Type: article

Abstract: >24 h). While additional optimization will be required to further improve its drug-like profile, TC7 emerged as the most promising compound evaluated in this study and represents a suitable starting point for future development. Collectively, these results serve as a proof of concept supporting a potential new codrugs strategy combining HO-1 and cSRC inhibition for glioblastoma therapy.

Source: RSC Medicinal Chemistry

DOI: 10.1039/d6md00227g

Authors: Valeria Pittalà, Loredana Salerno, Valeria Consoli, Agata Grazia D'Amico, Valeria Sorrenti, Luca Vanella, Giorgia Centamore, Chiara Terlati, Sara Mocka, Maria Nunziata Modica, Giuseppe Romeo, Marica Erminia Schiano, Federica Sodano, Mohamed A. Helal, Sebastiano Intagliata

Institutions: University of Catania, University of Naples Federico II, Suez Canal University, Zewail City of Science and Technology

Language: English

Topic: Heterocyclic Compound Synthesis and Bioactivity

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: European Commission, Ministero della Salute, Università di Catania, Ministero dell'Università e della Ricerca

Awards: G8688398193, G972786147

OpenAlex ID: W7220830976

FWCI:

Cites: 34

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Related to: 10