Work

Simultaneous activation and release of a microtubule inhibitor from amphiphilic polymeric nanoparticles

Year: 2026

Type: article

Abstract: tubulin polymerisation assays confirmed pronounced light-dependent inhibition, while cytotoxicity assays in cells validated concentration-dependent activity only after irradiation. This proof-of-concept study establishes a blueprint for integrating photocaging and photoswitching within nanocarriers to achieve dual activation and triggered release.

Source: Nanoscale Advances

DOI: 10.1039/d6na00763e

Authors: Harshit Singh, Anand Kumar Thotakura, A. P. Prakasham, Esmee de Korver, Anja R. A. Palmans

Institutions: Eindhoven University of Technology, Johns Hopkins University, Johns Hopkins Medicine

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,962