Work

Suspected Immune Checkpoint Inhibitor-Associated Ureteritis and Cystitis With Biopsy-Proven Acute Interstitial Nephritis

Year: 2026

Type: article

Abstract: Immune checkpoint inhibitors (ICIs) have transformed cancer treatment but can cause immune-related adverse events (irAEs) in almost any organ [1]. Kidney injury most often presents as acute interstitial nephritis (AIN), whereas ICI-associated ureteritis and cystitis (ICI-UC) are rare and may be mistaken for infection or obstruction [2-5]. Because renal biopsy has rarely been reported in ICI-UC, the contribution of intrinsic kidney injury remains uncertain. We report 2 patients with clinically suspected PD-1 inhibitor-associated ureteritis and cystitis accompanied by biopsy-proven AIN, highlighting intrinsic renal injury in addition to possible obstruction.

Source: Kidney International Reports

DOI: 10.1016/j.ekir.2026.107134

Authors: Chen Wang, Xin Zhang, Ying Tan, Xiao-Yan Liu, Xu-Jie Zhou

Institutions: Peking University, Peking University First Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Peking Union Medical College Hospital

Language: English

Topic: Cancer Immunotherapy and Biomarkers

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,800