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Enhancing double-duplex invasion by using multiple parallel-stranded peptide nucleic acids

Year: 2026

Type: preprint

Abstract: Peptide nucleic acids (PNAs) enable sequence-specific recognition of double-stranded DNA (dsDNA) via invasion complex formation. Here, we report a strategy using multiple parallel-stranded PNAs to enhance invasion efficiency. Cooperative binding of PNAs at adjacent target sites markedly improved invasion efficiency and enabled sequence-specific recognition of plasmid DNA under physiological conditions.

Source: ChemRxiv

DOI: 10.26434/chemrxiv.15010031/v1

Authors: Masanari Shibata, Kota Ito, Osami Shoji, Yuichiro Aiba

Institution: Nagoya University

Language: English

Topic: DNA and Nucleic Acid Chemistry

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W7220863194

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