A framework of biomarkers for skin aging: a consensus statement by the Aging Biomarker Consortium
Year: 2026
Type: article
Abstract: Skin is the largest organ of the human body and the first line of defense against the external environment. With the rapid growth of the older population in China, significant challenges have emerged in the prevention and management of age-associated diseases, while skin aging is closely associated with the aging of multiple organs. To address these challenges, the Aging Biomarker Consortium (ABC) has established an expert consensus on biomarkers of skin aging through a review of the literature and consultation with scientists and clinicians. This consensus provides a comprehensive evaluation of the key changes, characteristics, and biomarkers related to skin aging and proposes a systematic framework that categorizes these biomarkers into structural, functional, and humoral biomarkers. Within each dimension, the ABC recommends biomarkers supported by varying levels of clinical and experimental evidence for assessing both physiological and pathological changes in skin tissue during aging, aiming to establish a foundation for the prediction, diagnosis, early detection, and treatment of skin aging and related diseases, with the ultimate goal of improving skin tissue health and promoting healthy aging in elderly populations both in China and worldwide.
Source: Life Medicine
Authors: Yiya Zhang, Mengting Chen, Zhijin Li, Yingxue Huang, Qian Zhao, Ting Chen, Xiang Chen, Yong Cui, Zhili Deng, Yanan Du, Xinhua Gao, Jing-Dong Jackie Han, Yujun Hou, Zhe Jian, Di Li, Hang Li, Zhimiao Lin, Hong Liu, Wenjing Luo, Yuling Shi, Liangdan Sun, Juan Tao, Yang Wang, Fang Wang, Haijing Wu, Ran Xiao, Yong Yang, Nanze Yu, Bing Zhang, Furen Zhang, Lingjuan Zhang, Weiqi Zhang, Ming Zhao, Guang-Hui Liu, Gang Pei, Xiao Long, Jing Qu, Ji Li
Institutions: Central South University, Xiangya Hospital Central South University, Chinese Academy of Medical Sciences & Peking Union Medical College, Peking Union Medical College Hospital, Capital Medical University, Xuan Wu Hospital of the Capital Medical University, National Institute of Biological Sciences, Beijing, Tsinghua University, China-Japan Friendship Hospital, First Hospital of China Medical University, Peking University, Center for Life Sciences, Tongji University, Shanghai East Hospital, Xijing Hospital, Air Force Medical University, East China Normal University, Peking University First Hospital, Southern Medical University, Shandong First Medical University, Shanghai Skin Disease Hospital, North China University of Science and Technology, Wuhan Union Hospital, Huazhong University of Science and Technology, Second Xiangya Hospital of Central South University, Plastic Surgery Hospital, Chinese Academy of Medical Sciences Dermatology Hospital, Westlake University, Xiamen University, Chinese Academy of Sciences, Beijing Institute of Genomics, Institute of Zoology, University of Chinese Academy of Sciences, Beijing Institute for Stem Cell and Regenerative Medicine
Language: English
Topic: Skin Protection and Aging
Subfield: Dermatology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7220863751