Aptamers without SELEX: De novo design from protein structure in hours
Year: 2026
Type: article
Abstract: , 0.91-2.57 μM). A fourth DNA aptamer served as a capture reagent in a serum-based hybrid aptamer-antibody assay for Tau441. These applications support feasibility without establishing intended-target engagement in the cellular assay or a general success rate, positioning structure-based design as a complement to experimental selection.
Authors: Vladislava A. Dolgusheva, Iosif V. Leibin, Natalia O. Kudryashova, Artem R. Mukanov, Ivan I. Kuznetsov, Artem L. Manasyan, Gleb A. Pavlyuk, Ivan V. Mishkorez, Anna M. Keremet, Pavel R. Podlesnyi, Alexey N. Kalinkin, Kirill S. Avdeev, Maxim D. Kuznetsov, Nikita O. Parfenov, Stanislav M. Gromov, Dmitry Ufaev, Shamsudin S. Nasaev
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,900
OpenAlex ID: W7220900796