Myocardial lipid remodeling in patients with myocardial infarction undergoing cardiac surgery
Year: 2026
Type: article
Study design: Observational Study
Abstract: Myocardial lipid remodeling in myocardial infarction (MI) remains insufficiently characterized in human myocardium. Using liquid chromatography-mass spectrometry, we analyzed left atrial appendage tissue from patients with and without MI undergoing cardiac surgery. MI was characterized by reduced phospholipid species containing omega-3 polyunsaturated fatty acids (PUFAs) and myristic acid, together with reduced diacylglycerol species containing omega-3 PUFAs. Reduced phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol, and plasmalogens were observed, whereas triacylglycerols were enriched. Loss of polyunsaturated phospholipids and accumulation of relatively saturated triacylglycerols indicate a shift toward neutral lipid storage in human MI myocardium.
Authors: Tomoyuki Shiozawa, Tomoyasu Kadoguchi, Hyeon-Cheol Lee-Okada, Kazunori Shimada, Satoshi Matsushita, Takehiko Yokomizo, Tetsuro Miyazaki, Tatsuro Aikawa, Hidemori Hayashi, Satoru Suwa, Atsushi Amano, Yuji Nakazato, Hiroyuki Daida, Minoru Tabata, Naoshi Fukui, Nobuho Tanaka, Hirotaka Tsuno, Tohru Minamino
Language: English
Subfield: Biochemistry
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,020
Awards: Elucidation of physiological roles of fatty acyl species of late endosome-specific phospholipid BMP, Functional analysis of docosahexaenoic acids in late-endosome specific phospholipid BMP, G2954606471, The in vivo roles of polyunsaturated fatty acid species, G4492566916, Roles of polyunsaturated fatty acids in vivo, Lipidomics for association between atrial fibrillation and DHA-containing phospholipids, Elucidation of physiological roles of DHA-specific intracellular transport, リン脂質代謝調節に基づくサルコペニアの新規分子機序の解明, G7859663674, G8490252968, G8562563938, G8884028692, G9001001984, G9001067374, G9001165206
OpenAlex ID: W7220904490