Associations between a series of composite glucose-lipid indices and moderately increased albuminuria in patients with type 2 diabetes mellitus: a cross-sectional study
Year: 2026
Type: article
Study design: Observational Study
Abstract: Purpose: Diabetic kidney disease (DKD) represents one of the most significant microvascular complications associated with type 2 diabetes mellitus (T2DM). Moderately increased albuminuria, defined as a urinary albumin-to-creatinine ratio (UACR) of 30-300 mg/g, is widely recognized as an early indicator of renal injury in patients with T2DM. Previous studies have confirmed the role of glucolipotoxicity in the progression of DKD. Recently, a series of composite indices originating from blood glucose and lipid levels have been proposed, covering triglyceride-glucose index (TyG), triglyceride-glucose index to high-density lipoprotein cholesterol ratio (TyG/HDL-c), triglyceride glucose (TyG)-atherogenic index of plasma (AIP) index (TyG-AIP), cholesterol-high-density lipoprotein-glucose index (CHG) and triglyceride-glycated hemoglobin index (TyH-i). This study aimed to investigate the association between the aforementioned composite glucose-lipid indices and moderately increased albuminuria in patients with T2DM. Methods: The cross-sectional analysis included 1743 patients with T2DM. The clinical and laboratory data were obtained and related indices were calculated. Patients were categorized into the moderately increased albuminuria group (UACR 30-300 mg/g) and the normal to mildly increased albuminuria group (UACR < 30 mg/g). Results: This study encompassed 342 participants with moderately increased albuminuria. The composite glucose-lipid indices levels were elevated in the moderately increased albuminuria group (all P < 0.05). Univariate analysis revealed that these indices all exhibited a positive relationship with moderately increased albuminuria (all P < 0.05). Logistic regression analysis showed that TyH-i was the only composite glucose-lipid index retained in the logistic model (OR: 1.789; 95% CI: 1.276 - 2.510). In separate adjusted models, TyH-i remained independently associated with moderately increased albuminuria (OR: 2.279; 95% CI: 1.671 - 3.110). Conclusion: Among numerous composite glucose-lipid indices, TyH-i remained independently associated with moderately increased albuminuria after adjustment. However, its discriminatory performance was limited and did not differ significantly from that of the comparator indices.
Source: Frontiers in Endocrinology
Institutions: Linyi People's Hospital, Shandong Medical College
Language: English
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W7220968283