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Recurrent Sarcoidosis Presenting With Bilateral Leg Edema: A Case Report

Year: 2026

Type: article

Abstract: Background: Bilateral lower extremity edema may serve as an early clinical manifestation of pulmonary sarcoidosis. Identifying sarcoidosis as the underlying cause can be challenging in patients with or without a prior history of the disease, as lower extremity edema is not typically considered part of its clinical spectrum. Case Report: A 63-year-old man presented with a complex medical history, including non-Hodgkin lymphoma, bilateral renal cell carcinoma, colon cancer, and pleomorphic sarcoma of the upper extremity. He also had a history of recurrent pulmonary sarcoidosis. He reported a 6-month history of bilateral pitting lower extremity edema that developed several months before the onset of dyspnea. Conclusion: In patients with multiple comorbidities, recognizing sarcoidosis as a potential cause of bilateral lower extremity edema requires careful exclusion of systemic and malignant etiologies. Sarcoidosis should be considered when more common causes have been excluded.

Source: Journal of Clinical Practice and Research

DOI: 10.14744/cpr.2026.82224

Authors: Jacob Draves, Halil Tekiner, Steven H. Yale, Eileen S. Yale

Institutions: Midwestern University, Erciyes University, University of Central Florida, Lake Erie College of Osteopathic Medicine

Language: English

Topic: Sarcoidosis and Beryllium Toxicity Research

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7221025148