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Effect of delayed remote ischemic preconditioning on major cardiovascular and cerebrovascular events in major vascular surgery: the protocol of DRIPC randomized controlled trial

Year: 2026

Type: article

Abstract: Introduction: Although endovascular therapy has become the mainstream approach for major vascular surgery, patients undergoing such procedures are still classified as high-risk according to clinical guidelines. Remote ischemic preconditioning (RIPC) is a promising perioperative intervention strategy that has demonstrated acceptable safety and efficacy. Existing research indicates that delayed remote ischemic preconditioning (DRIPC) offers superior protective effects compared to preconditioning performed within 24 h before surgery. However, there is currently a lack of Level I evidence regarding the efficacy and safety of DRIPC in the perioperative period for vascular surgery patients. This study aims to provide high-level evidence on the effectiveness and safety of this intervention in a clinical setting. Methods and analysis: The trial is a single-center, prospective, double-blind, randomized controlled clinical trial. A total of 1,054 patients will be recruited. The primary endpoints of the study include major adverse cardiac and cerebrovascular events (MACCE) within 30 days postoperatively. Ethics and dissemination: This study has been approved by the Ethics Committee of West China Hospital of Sichuan University (approval number:2025-1846). The results will be submitted to a major clinical journal for peer review and publication. Clinical Trial registration: identifier ChiCTR2600116987.

Source: Frontiers in Cardiovascular Medicine

DOI: 10.3389/fcvm.2026.1952010