Pd-Cu-Ag Trimetallic Synergistic Catalysis for Decarboxylative/Deaminative Coupling of Carboxylic acids with Tertiary Amines
Year: 2026
Type: preprint
Abstract: Palladium-catalyzed coupling reactions, such as the well-established Suzuki and Hiyama couplings of benzylic ammonium salts, have been widely employed for the synthesis of diphenylmethanes. In contrast, the decarboxylative coupling strategy for constructing such scaffolds remains largely unexplored. This paper reports a Pd-Cu-Ag trimetallic synergistic catalytic system that enables efficient access to diphenylmethane derivatives through C(sp3)–N bond cleavage of amines and decarboxylation of carboxylic acids. This innovative methodology involves the in situ generation of carbene precursors via Pd-catalyzed, electron-deficient alkyne-mediated deamination of tertiary amines, along with the formation of activated nucleophilic species through Cu/Ag-catalyzed decarboxylation of carboxylic acids. The protocol features mild reaction conditions, high efficiency, and excellent functional group tolerance.
Source: ChemRxiv
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W7221065318