Work

Hsa_Circ_0000615-Encoded 250-Amino Acid Polypeptide Suppresses Epithelial Ovarian Cancer Progression via Promoting HMGB1 Nuclear Accumulation

Year: 2026

Type: article

Abstract: Circ_0615-encoded ZNF609-250aa acts as a tumor suppressor in EOC, partially through modulating ZNF609-250aa-HMGB1-related molecular events. This study provides novel mechanistic insights and promising pre-clinical candidate targets requiring further validation for EOC intervention.

Source: Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics

DOI: 10.32604/or.2026.087931

Authors: Ziyi Guo, Siyun Deng, Jiao Meng, Xiaofei Zhang, Yueyou Wang, Jiami Huang, Tonglu Li, Min Liu, Henghui Yang, Fangzhou Chen, Yuan Wang, Wei Meng, Shaojia Wang, Yanli Li

Institutions: Shanghai University, Shanghai Medical College of Fudan University, Fudan University, Obstetrics and Gynecology Hospital of Fudan University, Tongji University, Shanghai First Maternity and Infant Hospital, Shanghai University of Traditional Chinese Medicine, Shuguang Hospital, Second Military Medical University, Kunming Medical University, Shanghai Jiao Tong University, Shanghai First People's Hospital

Language: English

Topic: Circular RNAs in diseases

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: National Natural Science Foundation of China

Awards: G2496940853, G676735065, G8580203587

OpenAlex ID: W7221078364

FWCI:

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