Work

A Solution-Gated Graphene Transistor Sensor for the Detection and Quantification of Guanine Quadruplexes.

Year: 2026

Type: preprint

Abstract: SGGT G4 Detection 2 ABSTRACT. We report the design, realization, and testing of a Solution-Gated Graphene Transistor Sensor aimed at detecting and quantifying guanine quadruplexes. By using all-atom molecular dynamic simulations complemented with free energy methods we rationally design the architecture of the sensors, exploiting an economic and easy-available G4 ligand. The prototype of the sensor has shown the capacity to provide a linear response depending on the G4 concentration, hence showing the proof of concept of its applicability for G4 detection. The proposed sensors may allow the rapid detection of guanine quadruplexes in complex matrices, without relying on the use of antibodies or complex experimental apparatus.

Source: ChemRxiv

DOI: 10.26434/chemrxiv.15010179/v1

Authors: Aurianne Rainot, Dieu Linh Nguyen, Alessio Terenzi, Raphael Rouget, Stéphanie Grandemange, Giampaolo Barone, Florent Barbault, Benoit Piro, Antonio Monari

Institutions: Centre National de la Recherche Scientifique, Université Paris Cité, Interfaces Traitements Organisation et Dynamique des Systèmes, University of Palermo, CRAN

Language: English

Topic: Advanced biosensing and bioanalysis techniques

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: Laboratoire d'Excellence SEAM, Agence Nationale de la Recherche, Grand Équipement National De Calcul Intensif

Awards: G1420269888, G3336586620, G3543459289, G63545582, Université de Paris

OpenAlex ID: W7221079601

Cites: 57

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Related to: 10