Work

Post-translational modifications in rosacea

Year: 2026

Type: review

Abstract: Rosacea is a chronic inflammatory skin disease that primarily affects the central facial region, including the cheeks, nose, chin, and forehead. Its clinical features include episodic flushing, persistent erythema, telangiectasia, papulopustular lesions, and in severe cases, phymatous changes such as rhinophyma. Rosacea substantially impairs patients' quality of life, while current treatments focus primarily on symptom control. The pathogenesis of this disease involves abnormal immune responses, infiltration of immune cells, inflammatory reactions and angiogenesis, etc. Post-translational modifications (PTMs), particularly phosphorylation and ubiquitination, may play a role in initiating and sustaining these processes. This article reviews how PTMs such as phosphorylation and ubiquitination affect the pathogenesis of rosacea and assesses these PTM-regulated pathways as potential therapeutic targets.

Source: Frontiers in Immunology

DOI: 10.3389/fimmu.2026.1931025

Authors: Xuting Zhang, Hang Su, Wanying Deng, Fanghua Liu, Shougang Liu

Institutions: Panyu Hospital of Chinese Medicine, The First People's Hospital of Shunde, Southern Medical University, First Affiliated Hospital of Guangdong Pharmaceutical University, Ganzhou People's Hospital

Language: English

Topic: Acne and Rosacea Treatments and Effects

Subfield: Dermatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801