Research Progress and Applications of the Fundamental Principles of Soft Ionization Mass Spectrometry
Year: 2026
Type: preprint
Abstract: (1. Guangdong Huisheng Testing Technology Co., Ltd.) Abstract: Soft ionization mass spectrometry is widely applied in fields such as pharmaceuticals, cosmetics, environmental monitoring, and food safety; however, its fundamental principles remain subject to considerable debate, rendering it a "black-box" technology. This review summarizes the basic principles of electrospray ionization (ESI), matrix-assisted laser desorption (MALDI), and desorption electrospray ionization (DESI), and establishes "one theory, two equations, and three instruments" as the theoretical and practical foundation for soft ionization mass spectrometry. Furthermore, this study discusses the electromagnetic applications of soft ionization mass spectrometry, thereby expanding its scope of research and application.
Source: ChemRxiv
Authors: jiehong Luo, luo jiehong
Language: English
Subfield: Spectroscopy
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W7221105445