Work

Potential to modulate corneal epithelial repair via nitric oxide-releasing glycosaminoglycans

Year: 2026

Type: article

Abstract: barrier restoration. A derivative consisting of CS with prolonged NO release and low molecular weight HA with intermediate NO-release kinetics were identified as the most promising materials. The HA derivative enhanced epithelial migration even during later timepoints of the migration assays. A carboxymethylcellulose (CMC) gel formulation containing the HA derivative further promoted cell migration. In corneal tissue models, treatment with both the free and CMC-formulated NO-releasing HA enhanced restoration. Barrier recovery, as measured by transepithelial electrical resistance, confirmed restoration of tissue integrity post-wounding, concomitant with a cytokine milieu associated with pro-wound healing. Overall, NO-releasing, low molecular weight HA in a CMC gel formulation represents a promising bioactive strategy for promoting corneal wound repair.

Source: RSC Pharmaceutics

DOI: 10.1039/d6pm00190d

Authors: Margery E. Purvis, Madelyn P. Bucci, Tsian D. Ramrattan, Shannon M. Wallet, Mark H. Schoenfisch

Institutions: University of North Carolina at Chapel Hill, University of Florida

Language: English

Topic: Corneal Surgery and Treatments

Subfield: Ophthalmology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases