Work

Myeloid-derived suppressor cells in hematologic malignancies: A current state of the field

Year: 2026

Type: review

Abstract: Myeloid-derived suppressor cells are a pivotal component of the immunosuppressive tumor microenvironment in hematologic malignancies. Through diverse mechanisms, they promote disease progression, therapeutic resistance, and immune evasion. This comprehensive review synthesizes current evidence on the roles of myeloid-derived suppressor cells across major hematologic cancers and evaluates their prognostic significance, highlighting implications for patient stratification and potential therapeutic targeting.

Source: The Journal of Immunology

DOI: 10.1093/jimmun/vkag249

Authors: Yulia Nefedova, Dmitry I Gabrilovich

Institutions: The Wistar Institute, AstraZeneca (United States)

Language: English

Topic: Immune cells in cancer

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Cancer Institute