Earth-abundant 3d metal-catalyzed enantioselective catalysis towards the functionalization of E/Zalkenes mixtures.
Year: 2026
Type: preprint
Abstract: Enantioselective catalysis transforming alkenes to chiral molecules have been a breakthrough in the field of organic synthesis. Though a major challenge persists. The “privileged” chiral catalyst capacities depend on the geometry of the olefin substrate which can be either E or Z. Enantioselective catalysis allowing to convert both alkene stereoisomers to a single chiral molecule promises sustainable synthetic routes and novel mechanistic strategies towards chiral molecule synthesis. Enantioselective methods towards the functionalization of E/Z-alkenes, which has largely taken advantages of the recent development of earth-abundant 3d metal catalysis, are covered in this revue. An emphasis on the mechanisms accounting for the observed stereoconvergence and enantioselectivity is proposed.
Source: ChemRxiv
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W7221136769