Work

Hypogammaglobulinemia in Patients With Inflammatory Rheumatic Diseases Treated With IL-6 Receptor Inhibitors: A Retrospective Comparative Cohort Study.

Year: 2026

Type: article

Abstract: This poster presents the results of a retrospective comparative cohort study evaluating hypogammaglobulinemia and serum immunoglobulin levels in patients with inflammatory rheumatic diseases treated with interleukin-6 receptor inhibitors (IL-6Ri) compared with tumor necrosis factor inhibitors (TNFi). Patients treated with IL-6Ri had lower post-treatment IgG and IgA levels and a higher prevalence of hypogammaglobulinemia than those treated with TNFi. In multivariable analysis, baseline hypogammaglobulinemia and age ≥65 years were the main factors associated with post-treatment hypogammaglobulinemia. The findings highlight the importance of assessing baseline immunoglobulin levels and considering immunoglobulin monitoring in patients treated with IL-6 receptor inhibitors, particularly those with risk factors for hypogammaglobulinemia. This poster was presented at the American College of Rheumatology (ACR) Convergence 2026.

Source: Arthritis & Rheumatology

DOI: 10.5281/zenodo.23135294

Authors: Perea Martínez, Elisabet, Gómez Sabater, Silvia, Avilés Hernández, Antonio, Bermúdez García, Alejandra, Andrés, Mariano

Institutions: Hospital General de Elda, Hospital General Universitario de Alicante Doctor Balmis, Hospital Universitari Sant Joan D'Alacant, Universitat de Miguel Hernández d'Elx

Language: English

Topic: Rheumatoid Arthritis Research and Therapies

Subfield: Rheumatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $5,190