Work

Multi-responsive biopolymer–lipid hybrid nanocarriers for controlled doxorubicin delivery

Year: 2026

Type: article

Abstract: release studies under different conditions demonstrated pH-, enzyme-, and short-term temperature-dependent drug release. Compared with conventionally surfactant-stabilized nanoparticles, the developed HNPs exhibited significantly improved cytocompatibility toward mouse fibroblast (L929) cells. Additionally, DOX-loaded HNPs exhibited significant anticancer activity against human breast cancer (MCF-7) cells. Overall, the developed HNP system combines a surfactant-free formulation, enhanced cytocompatibility, and multi-stimuli-responsive drug release, making it a promising platform for controlled cancer drug delivery.

Source: Nanoscale Advances

DOI: 10.1039/d6na00677a

Authors: Öznur Safgöl, Banu Iyisan

Institution: Boğaziçi University

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,962