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Drug-Induced Linear IgA Bullous Dermatosis in a Critically Ill Patient Exposed to Polypharmacy

Year: 2026

Type: article

Abstract: Drug-induced linear IgA bullous dermatosis (DILABD) is typically associated with single-agent triggers, such as vancomycin, but its occurrence in the setting of polypharmacy is poorly understood. We report a 36-year-old female who developed DILABD during intensive care admission following exposure to multiple recognised triggering medications across different drug classes, with histological and immunofluorescence findings confirming the diagnosis. To our knowledge, this is the first reported case of DILABD arising in the context of such extensive polypharmacy, highlighting the diagnostic challenges in critically ill patients and raising the hypothesis that cumulative or synergistic drug effects may contribute to disease onset. However, this proposed interaction remains theoretical and cannot be established as a causal mechanism from a single case.

Source: Cureus

DOI: 10.7759/cureus.117739

Authors: Sarah Bufton, Emmanuel Odega, Rabia Sarfraz, Yasmeen Al-Sadek, Sheena Goyal

Institutions: University Hospitals of Derby and Burton NHS Foundation Trust, Kettering General Hospital

Language: English

Topic: Autoimmune Bullous Skin Diseases

Subfield: Dermatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7221338632