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Beyond BMI: Associations of Body-Shape Indices with CBC-Derived Systemic Inflammatory Indices in Adults with Metabolic Syndrome: A Cross-Sectional Study

Year: 2026

Type: article

Abstract: BACKGROUND/OBJECTIVES: Metabolic syndrome (MetS) is characterized by central adiposity, metabolic dysregulation, and low-grade inflammation, but body mass index (BMI) may not fully capture body-shape variation in established MetS. We investigated whether body-shape indices were associated with complete blood count (CBC)-derived systemic inflammatory indices after accounting for BMI. METHODS: In this cross-sectional study with prospective data collection, 331 adults with MetS were evaluated. Weight-adjusted waist index (WWI) was the primary anthropometric variable and systemic inflammation response index (SIRI) the primary inflammatory variable. Body roundness index (BRI), a body shape index (ABSI), conicity index, waist-to-height ratio (WHtR), and waist-to-hip ratio (WHR) were assessed as secondary anthropometric measures, together with the systemic immune-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR). Multivariable linear regression models were adjusted for age, sex, current smoking, and BMI. RESULTS: = 0.0038). None of the secondary anthropometric-inflammatory associations was statistically significant after false discovery rate (FDR) correction. Restricted cubic spline analysis showed no evidence of a nonlinear WWI-SIRI association (P-nonlinear = 0.582). Additional covariate analyses in which C-reactive protein, diabetes, estimated glomerular filtration rate, coronary artery disease and heart failure were added separately did not materially alter the WWI estimate. CONCLUSIONS: In adults with established MetS, we did not detect significant associations between WWI or other body-shape indices and CBC-derived systemic inflammatory indices after adjustment for BMI. These findings do not exclude smaller associations that may not have been detectable in this cohort.

Source: Metabolites

DOI: 10.3390/metabo16100762

Authors: Kamil Konur, Erol Karavar, Oğuzhan Kesen, Mümin Murat Yazıcı, Çağlayan Keklikkıran

Institution: Recep Tayyip Erdoğan University

Language: English

Topic: Adipokines, Inflammation, and Metabolic Diseases

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,258