Year: 2026
Type: article
Abstract: Brainstem gliomas (BSG) are rare in adults (less than 2% of all gliomas) and generally have a better prognosis than pediatric BSG, although outcomes remain heterogeneous. Many other central nervous system (CNS) tumors, as well as nontumoral lesions, have been described as differential diagnoses and should be kept in mind. Each case should be examined by neurosurgeons from specialized centers to determine the most appropriate surgical approach among stereotactic biopsy, open biopsy, and tumor resection. Surgery may sometimes be performed in expert centers. The main objectives of tumor tissue sampling are to perform histomolecular analyses to confirm the diagnosis, determine the tumor subtype, and identify potential prognostic and theranostic biomarkers. Tissue preservation is essential to ensure that sufficient tumor material is available for further molecular analyses for diagnostic or therapeutic purposes. Results of ctDNA detection in CSF should only be considered if they are positive. The management of BSGs in adults remains non-standardized, largely because most glioma trials exclude tumors located in this specific site. To date, no prospective trials have established clear treatment guidelines, and most of the available data come from retrospective studies or extrapolation of data from other locations. Radiotherapy (RT) is one of the main treatment options for BSGs in adults. The role of chemotherapy remains unclear due to limited data in literature and is currently being studied. Several molecular targets with therapeutic potential, including recurrent genetic mutations and fusion transcripts, have been identified in adult BSGs.
Source: The Oncologist
Authors: Florence Laigle-Donadey, Emmanuel Mesny, Franck Bielle, Aurélie Kas, Lucia Nichelli, Carole Ramirez, Laura Rozenblum, Olivier Langlois, Guido Ahle, Luc Bauchet, Loic Feuvret, Maxime Fontanilles, Julien Savatovsky, Jean-Marc Constans, Nadya Pyatigorskaya, Mehdi Touat, Julian Jacob, Emmanuel Jouglar, Luc Ollivier, Elsa Magro, Matthieu Boone, Apolline Monfilliette, Enora Vauleon, Philippe Menei, Ahmed Idbaih, Jean-Sébastien Guillamo, Elodie Vauleon, François Ducray, Caroline Dehais, Sylvie Grand, Bertrand Mathon, François Ducray, Guido Ahle, Fabien Almeirac, Luc Bauchet, Franck Bielle, Alice Bonneville-Levard, Mathieu Boone, Véronique Bourg, Charlotte Bronnimann, Marie-Dominique Cantal-Dupart, Hélène Castel Gandolfo, Olivier Chinot, Jean Marc Constans, Stefania Cuzzubbo, Amélie Darlix, Caroline Dehais, Frédéric Dhermain, François Ducray, Sarah Dumont, Walid Farah, Loïc Feuvret, Dominique Figarella Branger, Maxime Fontanilles, Jean Sébastien Guillamo, Khê Hoang Xuan, Jérôme Honnorat, Catherine Horodyckid, Andreas Hottinger, Ahmed Idbaih, Armelle Lacroux, Florence Laigle Donadey, Delphine Larrieu, Pierre Leblond, Florence Lefranc, Alice Leprince-Laurenge, Karima Mokhtari, Apolline Monfilliette Djelad, Georges Noel, Johan Pallud, Matthieu Peyre, Thiébaud Picart, Dimitri Psimaras, Carole Ramirez, Fabien Rech, Damien Ricard, Audrey Rousseau, Louis Royer-Perron, Marc Sanson, Emeline Tabouret, Luc Taillandier, Mehdi Touat, Renata Ursu, Pascale Varlet, Elodie Vauléon, Antoine Verger, Julie Vincent, Nadia Younan, Khê Hoang-Xuan Marine Abad, Homa Adle Biassette, Nozar Aghakhani, Guido Ahle, Franck Ah-Pine, Fabien Almairac, Romain Appay, Benjamin Auberger, Marie-Hélène Aubriot-Lorton, Pierre Kubicek, Luc Bauchet, Cecilia Rousselot-Denis, Michéle Bernier, Franck Bielle, Claire Blechet, Mathieu Boone, Veronique Bourg, Jean Boutonnat, Damien Bresson, Charlotte Bronniman, Francois Caire, Antoine Carpentier, Dominique Cazals-Hatem, Remi Chaix, Danchristian Chiforeanu, Guillaume Chotard, Elisabeth Cohen-Moyal, Philippe Colin, Thierry Cruel, Amelie Darlix, Caroline Dehais, Elise Deluche, Christine Desenclos, Emmanuel De Schlichting, Frederic Dhermain, Antoine Do Tran, Mathilde Duchesne, Francois Ducray, Julian Biau, Mathilde Ducloie, Julien Engelhardt, Thierry Faillot, Maxime Faisant, Walid Farah, Aude Aline Fardin, Fabien Forest, Guillaume Gauchotte, Edwina Girard, François Ghiringhelli, Catherine Godfraind, Carole Gourmelon, Thomas Graillon, Jean Sebastien Guillamo, Catherine Horodyckyd, Caroline Houillier, Noor Hamdan, Khê Hoang-Xuan, Mohamed Khettab, Olivier Langlois, Arthur Leclerc, Caroline Le Guérinel, Felix Lerintiu, Benoit Lhermitte, Delphine Loussouarn, Stéphane Lopez, Emmanuel Mandonnet, Florent Marguet, Benoit Marlier, Claude-Alain Maurage, David Meyronet, Serge Milin, Elise Morcos-Sauvain, Olivier Munier, Berangere Narcisco, Georges Noel, Johan Pallud, Julien Pavillet, Jean-Baptiste Pelletier, Matthieu Peyre, Francois Proust, Stephanie Puget, Isabelle Quintin-Roué, Thiébaud Picart, Carole Ramirez, Pierre Raynaud, Fabien Rech, Damien Ricard, Laurent Riffaud, Valérie Rigau, Pascal Roger, Audrey Rousseau, Cecilia Rousselot-Denis, Oumar Sacko, Romuald Seizeur, Emeline Tabouret, Luc Taillandier, Said Taha, Arnaud Tauziede-Espariat, Isabelle Tennevet, Emmanuelle Uro-Coste, Fanny Vandenbos-Burel, Pascale Varlet, Elodie Vauleon, Enora Vauleon, Nicolas Reyns, Clotilde Verlut, Michel Wager, Nadia Younan, Yordanka Yordanova, Ilyess Zemmoura
Institutions: Centre National de la Recherche Scientifique, Inserm, Sorbonne Université, Assistance Publique – Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Institut du Cerveau, Lyon 1 Université, Hospices Civils de Lyon, Laboratoire d’Imagerie Biomédicale, Hôpital Charles-Foix, Centre Hospitalier Universitaire de Saint-Étienne, Centre Hospitalier Universitaire de Rouen, Hopitaux Civils de Colmar, Centre Hospitalier Universitaire de Montpellier, Hôpital Gui de Chauliac, Centre Henri Becquerel, Génomique du cancer et du cerveau, Université de Rouen Normandie, Ramsay Santé Hôpital privé des Peupliers, Fondation Ophtalmologique Adolphe de Rothschild, Fondation de Rothschild, Centre Hospitalier Universitaire Amiens-Picardie, Université de Picardie Jules Verne, Université Paris Sciences et Lettres, Institut Curie, Institut de Cancérologie de l'Ouest, Université de Bretagne Occidentale, Centre Hospitalier Régional Universitaire de Brest, Laboratoire de Traitement de l'Information Médicale, Centre Hospitalier Universitaire de Lille, Oncogenesis Stress Signaling, Centre Eugène Marquis, Université de Rennes, Centre Hospitalier Universitaire d'Angers, Centre Hospitalier Universitaire de Nîmes, Centre de Recherche en Cancérologie de Lyon, Centre Hospitalier Universitaire de Grenoble
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,852
OpenAlex ID: W7221434510