Divergent Genomic Architectures and Immune Microenvironments of BCOR-altered versus YWHAE-rearranged HGESS
Year: 2026
Type: article
Study design: Observational Study
Abstract: High-grade endometrial stromal sarcoma (HGESS) is a rare and aggressive uterine mesenchymal neoplasm characterized by recurrent YWHAE::NUTM2 fusions and BCOR alterations. In this study, we performed integrated genomic and transcriptomic profiling of 45 HGESS and 23 low-grade endometrial stromal sarcoma (LGESS) cases to systematically characterize and compare their clinicopathological features, genomic alterations, transcriptomic profiles, immune microenvironments, and prognostic characteristics, and to explore potential subtype-specific therapeutic opportunities. Among the 45 HGESS cases, 26 underwent targeted DNA panel sequencing and 33 underwent whole-transcriptome sequencing (WTS). Among the 23 LGESS cases, 15 underwent targeted DNA panel sequencing and 11 underwent WTS.
Source: China National GeneBank DataBase
DOI: 10.26036/cnp0010210
Author: 谭彦铭(Yanming Tan)
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7221454893
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