Year: 2026
Type: preprint
Abstract: We introduce a new stochastic model of telomere length dynamics during hematopoiesis. The numerous cell divisions occurring in this setting makes telomere length dynamics, and in particular their attrition, a crucial aspect of hematopoiesis. After recalling the main aspect of the biological setting, we describe an individual based model of hematopoietic population cells. We then study its behaviour in the large population limit, as well as its fluctuations.
Source: arXiv (Cornell University)
Institutions: Centre National de la Recherche Scientifique, Institut national de recherche en sciences et technologies du numérique, Institut Élie Cartan de Lorraine, Université de Lorraine, Inserm, Défaillance Cardiovasculaire Aiguë et Chronique, Institut Universitaire de France, Institut de Recherche Mathématique Avancée, Université de Strasbourg
Language: English
Subfield: Mathematical Physics
Field: Mathematics
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W7221487223