Cap-assisted photodynamic therapy for esophageal cancer: precise irradiation field control for tumor-confined treatment
Year: 2026
Type: article
Abstract: Cap-assisted photodynamic therapy for esophageal cancer: precise irradiation field control for tumor-confined treatmentPhotodynamic therapy (PDT) is a safe and effective salvage treatment for local recurrence after chemoradiotherapy or radiotherapy for esophageal cancer. 1 However, adverse events such as esophageal stricture and perforation may occur. 2 The stricture is of particular concern as the risk increases with the circumferential extent of the lesion.To minimize this risk, avoiding unnecessary irradiation of the surrounding normal mucosa is important.In PDT, laser light is delivered endoscopically to the lesion after intravenous administration of a photosensitizer.A cap is attached to the endoscope tip to control the direction of irradiation; however, the cap does not fit against the esophageal mucosa, resulting in light leakage and an inconsistent irradiation distance.To overcome this limitation, we developed cap-assisted PDT (cap-PDT), wherein irradiation is delivered through a transparent cap mounted on the endoscope tip.The cap used for EMR-C 3 has an obliquely shaped tip that allows device positioning en face with the esophageal mucosa.For cap-PDT, the cap is covered with black tape and oriented such that the oblique opening faces the 12 o'clock direction of the endoscopic view.This configuration enables the en face visualization of the lesion with an up-angulation.The cap prevents laser light
Source: Endoscopy
DOI: 10.1055/a-2967-7860
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W7221511842