Work

Pulse therapy as a therapeutic alternative in refractory mucous membrane pemphigoid: A case report

Year: 2026

Type: article

Abstract: Mucous membrane pemphigoid (MMP) is a chronic autoimmune subepithelial blistering disorder with significant morbidity, especially in cases with ocular involvement, often requiring prolonged systemic immunosuppression. We report a 71-year-old male with refractory MMP involving oral and ocular mucosa, who showed inadequate response to daily systemic corticosteroids and mycophenolate mofetil and declined biologic therapy. He was treated with dexamethasone–cyclophosphamide pulse therapy, leading to marked clinical improvement; cyclophosphamide was later replaced with azathioprine due to leukopenia, following which complete remission was achieved and sustained. This case highlights pulse therapy as an effective, practical alternative in refractory MMP, particularly when conventional or biologic therapies are not feasible.

Source: Journal of Skin and Sexually Transmitted Diseases

DOI: 10.25259/jsstd_65_2026

Authors: Ria Susan Koshy, Thankappan Thonduparampil Pappen, Balachandran Parapattu Kunjukunju

Institution: Pushpagiri Medical College

Language: English

Topic: Autoimmune Bullous Skin Diseases

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7221522816