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Attenuated alpha state transitions and disrupted repetition-dependent temporal adaptation in mild cognitive impairment

Year: 2026
Type: preprint
Study design: Observational Study
Abstract: Mild cognitive impairment (MCI) may involve impaired dynamic regulation of brain states that is not captured by conventional resting-state electroencephalography (EEG). We quantified occipital alpha (8–12 Hz) transitions during three repeated eye-opening/eye-closure cycles in 60 healthy controls (HC) and 77 participants with MCI. Eye-state events were refined from frontal ocular artifacts. Transition magnitude was measured by the log-transformed post-/pre-event energy ratio, and transition success by the expected direction of alpha change. For canonical transitions meeting prespecified fit-quality criteria, mono-exponential fitting yielded transition onset (t onset ) and the post-onset time constant (τ). MCI showed weaker alpha suppression during eye opening, weaker alpha enhancement during eye closure, and lower odds of transition success. No significant group difference in τ was detected within the canonical quality-controlled subset. In contrast, t onset showed significant Group × Trial interactions in both conditions: HC developed later onset during eye opening and earlier onset during eye closure across repetitions, whereas MCI showed no comparable change. These findings suggest reduced alpha state-transition capacity and altered repetition-dependent temporal organization in MCI.
Source: medRxiv
DOI: 10.64898/2026.10.10.26365211
Language: English
Field: Medicine
Open Access status: green
OpenAlex ID: W7221549456
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