Osteoclast-like giant cell variant of bladder urothelial carcinoma with poor response to neoadjuvant chemotherapy managed by robot-assisted radical cystoprostatectomy: A case report
Year: 2026
Type: article
Study design: Case Report
Abstract: The osteoclast-like giant cell (OGC) variant of urothelial carcinoma is a rare histological entity characterized by an aggressive clinical course and diagnostic challenges. We report the case of a 62-year-old who presented with a muscle-invasive locally advanced urothelial carcinoma of the bladder. the tumor was resistant to chemotherapy. A completely robot-assisted radical cystoprostatectomy (RARC) with an intracorporeal Bricker ileal conduit urinary diversion was successfully performed. Histopathological evaluation of the surgical specimen demonstrated a OGC variant of bladder carcinoma. This case highlights the potential chemoresistance of the OGC variant to conventional platinum-based neoadjuvant regimens.
Source: Urology Case Reports
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,160
OpenAlex ID: W7221549620