Work

Bioorthogonal, twice-clickable fluorogenic probes for two-photon live-cell microscopy

Year: 2026

Type: article

Abstract: Two-photon-excitable profluorogenic probes capable of undergoing bioorthogonal reactions in complex biological media remain exceedingly rare, despite their tremendous potential for live-cell imaging. We herein describe two new acridane-based probes capable of undergoing double bioorthogonal click reactions with cyclooctynes and exhibiting promising photophysical properties for live-cell imaging.

Source: RSC Chemical Biology

DOI: 10.1039/d6cb00227g

Authors: Malo Gourvest, Emilie Plantiveau, Aurélie Rodriguez, Emma de Bastiani, Delphine Naud-Martin, Frédéric Bolze, Gilles Clavier, Kévin Renault, Frédéric Taran, Florence Mahuteau-Betzer

Institutions: Centre National de la Recherche Scientifique, Inserm, Université Paris Sciences et Lettres, Université Paris-Saclay, Chimie et Modélisation pour la Biologie du Cancer, Institut Curie, Médicaments et Technologies pour la Santé, Laboratoire de Chémo-biologie synthétique et thérapeutique

Language: English

Topic: Click Chemistry and Applications

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $1,962

Funders: École Normale Supérieure, Agence Nationale de la Recherche, Institut National de la Santé et de la Recherche Médicale, Conseil Régional, Île-de-France, Centre National de la Recherche Scientifique, Université Paris-Saclay

Awards: Clickable two-photon excitable fluorogenic probes for Drug Imaging in Living systems, G7655914274

OpenAlex ID: W7221549897

FWCI:

Cites: 4

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Related to: 10