Work

Selection and characterization of ssDNA aptamers targeting tick-borne encephalitis virus particles

Year: 2026

Type: article

Abstract: . Furthermore, sequence truncation yielded optimized variants that retained high target affinity, demonstrated enhanced serum stability over 24 h, and neutralized viral infection. These findings provide crucial functional validation of ssDNA aptamers targeting TBEV particles and support their development as antibody-independent platforms for diagnostic, antiviral, and targeted delivery strategies for TBEV and related flaviviruses.

Source: Molecular Therapy — Nucleic Acids

DOI: 10.1016/j.omtn.2026.103138

Authors: Yuji Fujii, Tomohiro Shinozaki, Minato Hirano, Mizuki Fukuta, Taiichi Sakamoto, Kentaro Yoshii

Institutions: Nagasaki University, National Research Center for the Control and Prevention of Infectious Diseases, Nagasaki University, Chiba Institute of Technology

Language: English

Topic: Advanced biosensing and bioanalysis techniques

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,900