Copper(II) Acetate-Catalyzed Aerobic Oxidation of N -(2-Arylacetyl)-1,3-oxazolidin-2-ones to 1,2-Dicarbonyl Compounds
Year: 2026
Type: article
Abstract: The copper-catalyzed aerobic oxidation of N-(2-arylacetyl)-1,3-oxazolidin-2-ones to the corresponding 2-oxo derivatives is described. The transformation is promoted by copper(II) acetate and 1,10-phenanthroline in DMSO at 30 °C and provides a wide range of 1,2-dicarbonyl compounds under mild reaction conditions. The method does not require bases or additional reagents, avoids prolonged heating, and proceeds through an operationally simple process with minimal waste generation. Eventually, the resulting α-keto imides can be readily converted into α-keto esters or amides and α-hydroxy derivatives.
Source: The Journal of Organic Chemistry
Institution: Universitat de Barcelona
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $4,500
OpenAlex ID: W7221583912