Comparative clinical and molecular profiling of papillary thyroid carcinomas with unilateral and bilateral lateral lymph node metastasis: a retrospective cohort study
Year: 2026
Type: article
Study design: Observational Study
Abstract: Purpose: Studies on pathological and genetic features related to lateral lymph node metastasis (LNM) in papillary thyroid carcinoma (PTC) remain limited. This study aimed to elucidate these features. Methods: A total of 135 patients with PTC who underwent total thyroidectomy with lateral neck dissection between 2000 and 2021 were retrospectively analyzed. Next-generation sequencing-based mutation panel analysis was conducted for 26 cases with unilateral or bilateral LNM. Results: fusion. Conclusion: Bilateral LNM cases showed higher nodal burden and a broader distribution of genomic alterations in this limited cohort. These findings suggest potential biological heterogeneity in PTC with lateral LNM and warrant validation in larger studies.
Institution: Catholic University of Korea
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7221630001