Work

Design, microwave-assisted domino synthesis, and biological evaluation of novel naphtho[2,3- b ]furan-4,9-diones as rigidified combretastatin A-4 analogs inducing G0/G1 cell cycle arrest and apoptosis

Year: 2026

Type: article

Abstract: values ranging from 1.90 to 11.48 µM. Flow cytometric analysis showed that compound 5c induced concentration-dependent cell cycle arest at G0/G1 phase and apoptosis in A549 cells. Molecular docking and density functional theory simulations predicted that 5c establishes a highly stable interaction network within the colchicine binding site of the α,β tubulin interface. Collectively, these findings highlight compound 5c as a highly promising preliminary cytotoxic lead for the development of novel anticancer agents.

Source: RSC Advances

DOI: 10.1039/d6ra08348j