Year: 2026
Type: preprint
Abstract: Acetylene is among the cheapest and most abundant C2 feedstocks, yet catalytic methods that exploit both of its π-bonds remain scarce, and its use in fine-chemical synthesis is 15 confined largely to mono-functionalization. Here we report the traceless bridging of aldehydes and formamides with a single acetylene molecule through a catalytic double hydroacylation, in which direct hydrogen-atom transfer generates acyl and carbamoyl radicals without decarbonylation or any sacrificial group. Coupling of two identical radicals assembles 1,4-diketones and 1,4-diamides in a single operation, whereas the sequential 20 delivery of two different radicals provides unsymmetrical 1,4-dicarbonyl products with good cross-selectivity. The transformation accommodates aromatic and aliphatic aldehydes and diverse formamides, proceeds under mild conditions with 100% atom economy, and requires
Source: ChemRxiv
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W7221689605