Year: 2026
Type: preprint
Abstract: Introduction Resection margins in oral squamous cell carcinoma (OSCC) are frequently inadequate. This study investigated the accuracy and diagnostic performance of ex-vivo 7T MRI against histology. Methods Fifty OSCC specimens underwent ex-vivo 7T MRI. Tumours were segmented on corresponding histology and twice on MRI: blinded to histology (radiologist segmentation; clinical practice) and using histology (histology-MR segmentation; MR-based ground truth). Resection margins were measured in five regions and compared with histology. Results Anterior and posterior margins were generally smaller on MRI than on histology (maximum mean difference -2.5 mm), whereas cranial, caudal and deep margins were generally larger on MRI (mean differences <1 mm). For close margins (<5 mm), sensitivity was 95% for histology-MR segmentations and 91% for radiologist segmentations, with 75% specificity for both. Conclusion Ex-vivo 7T MRI accurately measures resection margins and detects close margins with high sensitivity. A future clinical trial will determine whether intraoperative implementation reduces inadequate margins and adjuvant treatment.
Source: medRxiv
Institutions: University Medical Center Utrecht, Utrecht University
Language: English
Topic: Head and Neck Cancer Studies
Subfield: Otorhinolaryngology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7221694407