Work

Electrochemical (3+2) Cycloaddition of Enamides and 4-(Bocamino)phenol for the Synthesis of 2-Aminodihydrobenzofurans

Year: 2026

Type: preprint

Abstract: Synopsis: We report a simple electrochemical protocol to prepare 2-amino-dihydrobenzofurans from enamides. In contrast to previously reported approaches relying on stoichiometric chemical oxidants or transition metal catalysis of prefunctionalized compounds, the present method directly couples 4-(Boc-amino)phenol through anodic activation to a wide range of enamides, using inexpensive graphite electrodes in an undivided cell.

Source: ChemRxiv

DOI: 10.26434/chemrxiv.15010367/v1

Authors: Maurice Peene, Louis Rouseu, Marios kidonakis

Institution: Ghent University

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: Fonds Wetenschappelijk Onderzoek, Vlaamse regering

Award: Triazolinediones as site-selective C-H functionalization reagents via hydride abstraction

OpenAlex ID: W7221701224

Cites: 18

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Related to: 10