Work

Discovery of GTA182, a Novel CNS-Active Tricyclic Amide MTA-Cooperative PRMT5 Inhibitor for MTAP -Deleted Cancers

Year: 2026

Type: article

Source: Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.6c02121

Authors: Bing Yao, Weifeng Mao, Minghua Wang, Junqing Zhang, Shanshan Xie, Kai Cheng, Xinbo Hu, Wei Liu, Xiangping Zhang, Zhengqing Zhu, James D. Joseph, Mingxi Li, Xiaohui Gu, Fred Aswad

Institution: Apeiron Biologics (Austria)

Language: English

Topic: Cancer-related gene regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: closed

OpenAlex ID: W7221747274

FWCI:

Cites: 74

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