Abdominal aortic angiosarcoma following endovascular aneurysm repair: case report and analysis of existing literature
Year: 2026
Type: article
Study design: Case Report
Abstract: Abdominal aortic angiosarcoma following endovascular aneurysm repair (EVAR) is an exceptionally rare and aggressive malignancy that may mimic common EVAR-related complications. We report the case of a 72-year-old man who presented with progressive lower back pain and was initially suspected of having a graft infection. Imaging revealed a periaortic mass involving a previously treated abdominal aortic aneurysm. Biopsy confirmed aortic angiosarcoma. No regional lymph node or distant metastases were identified. The patient underwent neoadjuvant chemotherapy with gemcitabine and docetaxel, followed by radiotherapy and surgical resection of the abdominal aorta and EVAR graft with aortic reconstruction. Histopathological examination demonstrated complete pathological response without evidence of residual angiosarcoma. Our literature review identified only 21 reported cases of abdominal aortic angiosarcoma following EVAR, including the present case, underscoring the exceptional rarity of this entity and the limited evidence available to guide diagnosis and treatment. This case highlights the importance of considering aortic angiosarcoma in patients with persistent symptoms and atypical periaortic findings after EVAR and suggests that early biopsy and a multidisciplinary, multimodal treatment approach may improve outcomes despite the generally poor prognosis associated with this disease.
Source: Frontiers in Surgery
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W7221762977