Evaluation of mitral regurgitation severity in type 1 acute myocardial infarction: correlation with wall motion score index and infarct location
Year: 2026
Type: article
Study design: Observational Study
Abstract: Ischemic mitral regurgitation (MR) is One common and important prognostic consequence of acute myocardial infarction (AMI). Although it is frequently used to evaluate ventricular function, left ventricular ejection fraction (LVEF) may underestimate early localized dysfunction that contributes to MR. To determine whether WMSI provides additional clinical value for the early assessment of MR severity in patients with acute myocardial infarction undergoing PCI, future prospective, multicenter trials involving longitudinal follow-up are necessary. 218 patients with type 1 AMI who were assessed before PCI at a tertiary care facility between January 2024 and July 2025 were included in this cross-sectional observational analysis. Every individual had transthoracic echocardiography to determine the site of the infarct, WMSI, LVEF, and MR severity using a multiparametric method. Chi-square tests and ordinal logistic regression were used to examine relationships between MR grade and clinical, demographic, and echocardiographic factors. Grade 2 MR (44.4%) was the most prevalent among 218 patients, followed by Grade 1 (26.1%) and Grade 3 (25.2%). While lower LVEF was linked to higher MR severity, higher BMI, older age, larger LA diameter, male sex, and hypertension were all independently linked to rising MR grade. MR grade was not independently correlated with WMSI (OR = 1.985, 95% CI: 0.703–5.681; p = 0.197). Only SWMI among infarct areas was significantly correlated with MR grade (OR = 0.071, 95% CI: 0.008–0.480; p = 0.010). Similar discrimination was shown by ROC analysis for LVEF (AUC = 0.800, 95% CI: 0.742–0.858) and WMSI (AUC = 0.794, 95% CI: 0.726–0.862). The degree of mitral regurgitation in individuals with type 1 acute myocardial infarction prior to PCI indicates both localized and widespread left ventricular dysfunction. Beyond traditional LVEF evaluation, the Wall Motion Score Index may improve early risk classification as a sensitive early indication of ischemia MR. Not applicable.
Source: BMC Cardiovascular Disorders
Institution: Symbiosis International University
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,090
OpenAlex ID: W7221767129
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