Work

Epidemiology, determinants, and microbiological profile of implant-associated infections following intramedullary nailing in a tertiary hospital in Ethiopia

Year: 2026

Type: article

Abstract: BACKGROUND: Implant-associated infections after intramedullary nailing (IMN) are a major cause of morbidity in patients with long bone fractures. This study aimed to determine the magnitude, determinants, and microbiological profile of such infections in a tertiary hospital in Ethiopia. METHODS: A hospital-based cross-sectional study was conducted among 260 patients who underwent IMN for lower extremity long bone fractures between January 2021 and December 2023. Clinical data, operative details, and microbiological results were collected, and logistic regression was applied to identify determinants of infection. RESULTS: The overall infection rate was 8.46% (95% CI: 5.38-12.53; 22/260), comprising 4.62% deep and 3.85% superficial infections. We found that emergency surgery and hospital stay longer than 14 days were independently associated with an increased risk of infection. Among the limited number of culture-positive infections, Gram-negative bacteria predominated, with Escherichia coli as the most frequently identified pathogen. CONCLUSION: The infection rate was higher than in many other settings, underscoring the need for improved perioperative infection prevention and reduced hospital stays. Findings highlight the importance of perioperative optimization and hospital infection control in LMICs.

Source: Archives of Orthopaedic and Trauma Surgery

DOI: 10.1007/s00402-026-06535-6

Authors: Abebaw Muhabaw Zegeye, Suleiman Ayalew Belay, Ephrem Bekele Kebede, Birlew Teshome Alemayehu, Sileshi Serebe Zeleke, Yohannis Derbew Molla

Institution: University of Gondar

Language: English

Topic: Orthopedic Infections and Treatments

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,590