Work

A urothelial cell carcinoma in the abdominal cavity after salpingectomy for tubo-ovarian carcinoma risk reduction in a BRCA1 pathogenic variant carrier

Year: 2026

Type: article

Abstract: Introduction Risk reducing salpingo-oophorectomy with delayed oophorectomy is an alternative preventive strategy to prevent tubo-ovarian carcinoma. Its oncological safety is currently under investigation within different clinical trials. Case After a previous salpingectomy, a 37-year-old BRCA1 pathogenic variant carrier developed a carcinoma in the abdominal cavity, which had spread extensively throughout the abdomen. She had chosen the alternative risk-reducing salpingectomy with delayed oophorectomy as tubo-ovarian carcinoma prevention strategy The salpingectomy was performed at age 35, two years prior to the diagnosis of carcinoma. Radiologically, the tumor appeared to originate from the left ovary with lymphadenopathy, hydronephrosis, and peritoneal carcinomatosis. Incomplete debulking surgery was performed with en bloc resection of the uterus, ovaries, rectosigmoid,appendix, and distal part of the left ureter. After extensive analysis with pathology revision, the tumor was classified as a poorly differentiated sarcomatoid urothelial cell carcinoma. Molecular testing showed the tumor had a BRCA1 pathogenic variant. Conclusion This case illustrates the importance of a structured clinical trial setting for the investigation of cancer prevention strategies as it ensures extensive follow-up and comprehensive pathological (re)assessment to warrant patient safety.

Source: Gynecologic Oncology Reports

DOI: 10.1016/j.gore.2026.102232