Can PIM-3 score predict risk for neonatal mortality vs. SNAPPE II and SNAP II scores in a tertiary surgical neonatal intensive care unit?
Year: 2026
Type: article
Study design: Observational Study
Abstract: Objective: To assess the accuracy of PIM-3 score in predicting neonatal mortality by comparing it to two established neonatal mortality scores, SNAPPE II and SNAP II. Study design: Retrospective study of all admissions to Great Ormond Street Neonatal Intensive Care Unit (NICU) for the calendar year of 2022. Individual scores were calculated for all admissions using the electronic health records and referring or transfer notes. Admissions <12 h and those with missing data were excluded. The sensitivity and specificity of each score at potential cut-off values were calculated and plotted as a receiver operator curve (ROC), by calculating the Area Under the Curve (AUC) and confidence intervals for each one. score. Subgroup analysis was used to assess the AUC of each score for gender, prematurity, age at admission, gestational weight, ventilation status, and whether the admission was planned. Results: The PIM-3 score had a higher AUC of 0.788 compared to SNAPPE II (0.738), and SNAP II (0.706), with optimal cut-off values at 9%, 30 and 11, respectively. The PIM-3 score performed better in preterm, lower birth weight and ventilated neonates. It also demonstrated a better correlation to length of stay compared to the other two scores, although statistically not significant. Conclusion: The PIM-3 score was equal to, or marginally better in predicting mortality in a mixed neonatal population compared to SNAPPE II and SNAP II. Further prospective analysis in a larger patient cohort is required to reproduce and validate its efficacy.
Source: Frontiers in Pediatrics
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W7221775757