Clinical significance of myocardial layer-specific ventricular-arterial coupling index in community populations
Year: 2026
Type: article
Abstract: Background: Traditional global indices of ventricular-arterial coupling (VAC) often fail to reflect regional myocardial mechanics. The aim of this study was to establish and validate novel layer-specific artery-myocardial strain coupling indices by integrating arterial stiffness with layer-specific global circumferential strains (GCSs), and to determine the clinical significance of these layer-specific VAC indices across different age groups. Methods: ). Multiple linear regression analyses were performed to identify independent determinants of these coupling ratios, and receiver operating characteristic (ROC) curves were constructed to compare the diagnostic performance between novel and traditional VAC indices. Results: significantly surpassed that of traditional VAC indices, such as ventricular-vascular coupling index (VVI), across all age strata. Conclusions: Independently determined by age and LVEF, the novel layer-specific AVI/GCS indices are significantly superior to traditional VVI in detecting age-related impairments in cardiovascular function. By revealing distinct transmural functional heterogeneity across myocardial layers, these indices offer a multidimensional framework for evaluating age-related cardiovascular functional alterations.
Institutions: Shanxi Medical University, Shanghai First People's Hospital, Shanxi Academy of Medical Sciences, Nanjing Medical University, Fujian University of Traditional Chinese Medicine, Chengdu Medical College, Shanghai Jiao Tong University, Shanghai University of Traditional Chinese Medicine, Shanghai Guanghua Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai Children's Hospital
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7221777932