Work

Experimental and Computational Investigation into the Formation, Rearrangements, and Capture of Carbonyl-Substituted Bicyclobutonium and Related Cations

Year: 2026

Type: article

Abstract: We report the combined experimental and computational investigation of systems involving carbonyl-containing bicyclobutonium cation intermediates generated by I(III)-mediated oxidative Umpolung or acylation of cyclobutenes. The regio- and diastereoselectivity of their nucleophilic capture relies on the in situ formation of “locked” oxocarbenium intermediates and “unlocked” cyclobutyl cations.

Source: JACS Au

DOI: 10.1021/jacsau.6c01309